A pair of enantiomeric 5-oxabicyclic[4.3.0]lactam derivatives and one new polyketide from the marine-derived fungus Penicillium griseofulvum

作者：Yang, Jian-Kun; Zhang, Bin; Gao, Tong; Yang, Meng-Yue; Zhao, Guo-Zheng; Zhu, Hua-Jie; Liu, Li^*; Cao, Fei^*

来源：Natural Product Research, 2018, 32(19): 2366-2369.

DOI：10.1080/14786419.2017.1410815

• Penicillium griseofulvum
• bicyclic lactam
• polyketide
• antibacterial activity

A pair of enantiomeric 4-oxabicyclic[4.3.0]lactam derivatives, (+)- and (-)-penicilactam A (1), and one new polyketide derivative penicitrinone F (2) were isolated from the marine-derived fungus Penicillium griseofulvum GT-10. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses combined with the calculated ECD spectra. Penicitrinone F (2) had moderate inhibitory activity towards Bacillus subtilis with a MIC value of 6.3M.
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• 出版日期2018
• 单位河北大学