NF-kappa B and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

作者：Ersing Ina; Bernhardt Katharina; Gewurz Benjamin E^*

来源：Viruses-Basel, 2013, 5(6): 1587-1606.

DOI：10.3390/v5061587

• herpesvirus
• apoptosis
• cancer
• innate immunity
• transformation
• integral membrane protein
• signal transduction
• proliferation
• ubiquitin
• lymphoma
• oncogene

The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-kappa B, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-kappa B activity, and rapidly undergo apoptosis upon NF-kappa B blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-kappa B and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-kappa B and IRF7 pathway activation.

• 出版日期2013-6