Diversified assembly of perfluoroalkyl-substituted furans and 2,5-dihydrofuran-2-ols

作者：Chen, Guofei; He, Guangke; Xue, Can; Fu, Chunling; Ma, Shengming^*

来源：Tetrahedron Letters, 2011, 52(2): 196-198.

DOI：10.1016/j.tetlet.2010.10.085

• 2,3 WITTIG REARRANGEMENT
• EFFICIENT SYNTHESIS
• ALLENIC ACIDS
• BUTENOLIDES
• INHIBITORS
• PHSECL
• ESTERS

We have developed a facile and effective synthesis of 3-iodofurans from 3-monosubstituted 1,2-allenyl perfluoroalkyl ketones or 2-hydroxy-4-iodo-2,5-dihydrofurans from 3,3-disubstituted 1,2-allenyl perfluoroalkyl ketones. The perfluoroalkyl substituent and the amount of water in the solvent are important for the success of this electrophilic cyclization.

• 出版日期2011-1-12
• 单位浙江大学