Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways

作者：Nix Paola; Hisamoto Naoki; Matsumoto Kunihiro; Bastiani Michael^*

来源：Proceedings of the National Academy of Sciences, 2011, 108(26): 10738-10743.

DOI：10.1073/pnas.1104830108

• Caenorhabditis elegans
• MAPK signaling
• laser axotomy

Signaling pathways essential for axon regeneration, but not for neuron development or function, are particularly well suited targets for therapeutic intervention. We find that the parallel PMK-3(p38) and KGB-1(JNK) MAPK pathways must be coordinately activated to promote axon regeneration. Axon regeneration fails if the activity of either pathway is absent. These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3 (p38) and KGB-1(JNK).

• 出版日期2011-6-28