The Effect of Topical Diclofenac Sodium 0.1% on the Corneal Epithelial Healing after Photorefractive Keratectomy

作者：Hashemian Mohammad Nasser; Rahimi Firoozeh; Alipour Fatemeh; Ahmadraji Ali Asghar; Torabi Hamid Reza^*; Tavakoli Niloofar; Moghadam Reza Soltani

来源：Iranian Journal of Ophthalmology, 2011, 23(2): 27-30.

• Diclofenac Sodium
• Photorefractive Keratectomy
• Epithelial Healing

Purpose: To evaluate the effect of topical diclofenac sodium 0.1% on the corneal epithelial healing after photorefractive keratectomy (PRK)
Methods: In this prospective randomized double blind clinical trial, PRK was performed on 82 patients. Thirty-three cases of them receiving topical diclofenac four times per day after surgical procedure and 45 patients did not receive this medication as a control group. Patients were compared for corneal epithelial healing after treatment.
Results: Statistically significant delayed epithelial healing has been found in the treatment group 24 hours after PRK but corneal reepithelialization has been completed in all patients four days after surgery.
Conclusion: Postoperative topical diclofenac used following PRK may delay the epithelial healing.

• 出版日期2011