A new method for synthesis of mcrocyclic lactones via malania olceifera chum oil

作者：Liu Xiong Min^*; Li Wei Guang; Li Piao Ying; Zhou Yong Hong

来源：Chemical Journal of Chinese Universities, 2007, 28(5): 897-899.

• malania olceifera chum oil
• cyclopentadecanolide
• ozonization
• macrocyclic lactone

Synthesis of mcrocyclic lactones has been applied to medical and flavor field. Triglycerides(2) of omega-hydroxycarboxylic acids synthesized from malania oleifera chum oil(l) via ozonization and reduction, and compound 2 were catalytically transformed to macrocyctic lactones(3). This is a new method involving fewer steps and a 61% yield of cyclopentadecanolide was obtained. The reactive properties of macrolactonization of omega-hydroxycarboxylic acids were also studied. The result obtained shows that the priority order of macrolactonization as follows: 11-undecalactone > cyclotridecanolide > cyclopentadecanolide, i.e. the short chain omega-hydroxycarboxylic acids were preferentially cyclized.

• 出版日期2007-5
• 单位广西大学