Mixed micelle cloud point-magnetic dispersive mu-solid phase extraction of doxazosin and alfuzosin

作者：Gao Nannan; Wu Hao^*; Chang Yafen; Guo Xiaozhen; Zhang Lizhen; Du Liming; Fu Yunlong

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2015, 134: 10-16.

DOI：10.1016/j.saa.2014.06.095

• Mixed micelle cloud point extraction
• Magnetic dispersive mu-solid phase extraction
• Doxazosin
• Alfuzosin
• Fluorescence

Mixed micelle cloud point extraction (MM-CPE) combined with magnetic dispersive mu-solid phase extraction (MD-mu-SPE) has been developed as a new approach for the extraction of doxazosin (DOX) and alfuzosin CALF) prior to fluorescence analysis. The mixed micelle anionic surfactant sodium dodecyl sulfate and non-ionic polyoxyethylene(7.5)nonylphenylether was used as the extraction solvent in MM-CPE, and diatomite bonding Fe3O4 magnetic nanoparticles were used as the adsorbent in MD-mu-SPE. The method was based on MM-CPE of DOX and ALF in the surfactant-rich phase. Magnetic materials were used to retrieve the surfactant-rich phase, which easily separated from the aqueous phase under magnetic field. At optimum conditions, a linear relationship between DOX and ALF was obtained in the range of 5-300 ng mL(-1), and the limits of detection were 0.21 and 0.16 ng mL(-1), respectively. The proposed method was successfully applied for the determination of the drugs in pharmaceutical preparations, urine samples, and plasma samples.

• 出版日期2015-1-5
• 单位山西师范大学