New antibacterial xanthone from the marine sponge-derived Micrococcus sp EG45

作者：Eltamany Enas E; Abdelmohsen Usama Ramadan; Ibrahim Amany K; Hassanean Hashim A; Hentschel Ute; Ahmed Safwat A^*

来源：Bioorganic & Medicinal Chemistry Letters, 2014, 24(21): 4939-4942.

DOI：10.1016/j.bmcl.2014.09.040

• Actinomycetes
• Micrococcus sp.
• Spheciospongia vagabunda
• Xanthone
• Antimicrobial activity

Microluside A [4 (19-para-hydroxy benzoyloxy-O-beta-D-cellobiosyl), 5 (30-para-hydroxy benzoyloxy-O-beta-D-glucopyranosyl) xanthone (1)] is a unique O-glycosylated disubstituted xanthone isolated from the broth culture of Micrococcus sp. EG45 cultivated from the Red Sea sponge Spheciospongia vagabunda. The structure of microluside A was determined by 1D- and 2D-NMR techniques as well as high resolution tandem mass spectrometry. The antimicrobial activity evaluation showed that 1 exhibited antibacterial potential against Enterococcus faecalis JH212 and Staphylococcus aureus NCTC 8325 with MIC values of 10 and 13 mu M, respectively.

• 出版日期2014-11-1