An 18-norspirostanol saponin with inhibitory action against COX-2 production from the underground part of Trillium tschonoskii

作者：Wang, Junzhi; Zou, Kun^*; Zhang, Yanming; Liu, Chuang; Wu, Jun; Zhou, Yuan; Dan, Feijun; Zhang, Yaxiong

来源：Chemical & Pharmaceutical Bulletin, 2007, 55(4): 679-681.

DOI：10.1248/cpb.55.679

• Trillium tschonoskii
• 18-norspirostanol saponin
• COX-2
• folk medicine
• trillenoside A

A novel 18-norspirostanol saponin (1), along with Trillenoside A (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 mu g/ml.

• 出版日期2007-4
• 单位三峡大学; 中国科学院; 中国科学院南海海洋研究所