MicroRNA-409-3p suppresses cell proliferation and cell cycle progression by targeting cyclin D2 in papillary thyroid carcinoma

作者：Zhao, Zhijun; Yang, Fei; Liu, Yan; Fu, Kai; Jing, Shanghua^*

来源：Oncology Letters, 2018, 16(4): 5237-5242.

DOI：10.3892/ol.2018.9246

• papillary thyroid carcinoma
• microRNA-409-3p
• cell proliferation
• cyclin D2

MicroRNAs (miRs) function as tumor suppressors or oncogenes in tumor development and progression. The present study reported that miR-409-3p was significantly downregulated in human papillary thyroid carcinoma (PTC) tissues and cell lines. Overexpression of miR-409-3p suppressed cell proliferation and induced cell cycle G(0)/G(1) phase arrest in PTC cells. Further study revealed that the transcriptional regulator cyclin D2 was a target of miR-409-3p, as miR-409-3p bound directly to its 3-untranslated region and the miR-409-3p mimic reduced the protein expression levels of cyclin D2. In addition, restoration of cyclin D2 expression reversed the inhibitive effect of miR-409-3p on PTC cells. To the best of our knowledge, these findings demonstrate for the first time that miR-409-3p functions as a tumor suppressor in PTC and could serve as an efficient agent for therapy of PTC.

• 出版日期2018-10
• 单位河北医科大学