Assessing Cell and Organ Senescence Biomarkers

作者:Bernardes de Jesus Bruno; Blasco Maria A*
来源:Circulation Research, 2012, 111(1): 97-109.
DOI:10.1161/CIRCRESAHA.111.247866

摘要

A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers. (Circ Res. 2012;111:97-109.)

  • 出版日期2012-6-22