科研之友
微信
新浪微博
Facebook
分享链接
摘要
To guide the molecular design of the pH-sensitive triblock amphiphilic polymer MPEG-PAE-PLA and the formula design of its doxorubicine (DOX)-loaded micelles, dissipative particle dynamics (DPD) simulations are employed to investigate the aggregation behaviors of the DOX-loaded micelles. The simulation results showed that the aggregate morphologies of micelles and DOX distribution are influenced by degree of polymerization of blocks, and the proposed structure of polymer is MPEG44-PAE3-PLA4. With different contents of polymer or DOX, different aggregate morphologies of the micelles, like microsphere, spindle/column, reticulation or lamella are observed. To prepare the micro-spherical DOX-loaded micelles, the polymer content is proposed as 10%15%, and the DOX content less than 10%.
