A Lactobacillus plantarum strain isolated from kefir protects against intestinal infection with Yersinia enterocolitica O9 and modulates immunity in mice

作者：De Montijo Prieto Soumi; Moreno Encarnacion; Bergillos Meca Triana; Lasserrot Agustin; Ruiz Lopez Maria Dolores; Ruiz Bravo Alfonso; Jimenez Valera Maria^*

来源：Research in Microbiology, 2015, 166(8): 626-632.

DOI：10.1016/j.resmic.2015.07.010

• Probiotic
• Lactobacillus plantarum
• Yersinia enterocolitica
• Infection
• Cytokines
• Immunomodulation

Lactobacillus plantarum C4, previously isolated from kefir and characterized as a potential probiotic strain, was tested for its protective and immunomodulatory capacity in a murine model of yersiniosis. The inoculation of BALB/c mice with a low pathogenicity serotype O9 strain of Yersinia enterocolitica results in a prolonged intestinal infection with colonization of Peyer's patches. Pretreatment with C4 was without effect on fecal excretion of yersiniae, but shortened the colonization of Peyer's patches. This protective effect was associated with pro-inflammatory status in the intestinal mucosa (TNF-alpha production in infected mice was increased by C4) and an increase in total IgA secretion. At a systemic level, C4 did not promote a pro-inflammatory response, although production of the immunoregulatory cytokine IFN-gamma was enhanced. These findings suggest that L. plantarum C4 can increase resistance to intestinal infections through its immunomodulatory activity.

• 出版日期2015-10