Performance Evaluation of a Novel Potentiometric Membrane Sensor for Determination of Atorvastatin in Pharmaceutical Preparations

作者：Ahmadi Farhad^*; Asaadi Nasim

来源：Iranian Journal of Pharmaceutical Research, 2013, 12(4): 645-657.

• Atorvastatin
• PVC membrane
• Potentiometric sensor
• Analysis of pharmaceutical preparation

A novel potentiometric ion-selective PVC membrane sensor for analysis of atorvastatin (AT) in pharmaceutical preparations based on atorvastatin-(tetraphenyl borate), (AT-(TPB)(2)) as sensing element, tetraphenyl borate as additive and tris-2-ethyl-hexyl phosphate (TOP) as plasticizer solvent was prepared. The electrode shows a good Nernestian response over the concentration range of 0.09-5586 mu g mL(-1) of AT with slope of 30.1 +/- 0.1 mV/decade and limit of detection0.056 mu g mL(-1). The response time of sensor is fats (less than 10 sec) and could be used for about one month in the pH range of 4.5-8.0. The electrode exhibit good selectivity for the AT in the presence of large amount of co-drugs and inorganic cations. The method is precise and accurate with mean relative standard deviation of <2%. Atorvastatin is determined successfully in several tablets by the proposed membrane.

• 出版日期2013