A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

作者：Huang Guan Jhong; Reddy M Vijaya Bhaskar; Kuo Ping Chung; Huang Chieh Hung; Shih Hung Cheng; Lee E Jian; Yang Mei Lin; Leu Yann Lii; Wu Tian Shung^*

来源：European Journal of Medicinal Chemistry, 2012, 48: 371-378.

DOI：10.1016/j.ejmech.2011.12.008

• Viscolin
• Anti-Inflammatory
• Macrophages
• iNOS
• COX-2
• lambda-Carrageenin

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERIC for the activation of NF-kappa B in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

• 出版日期2012-2
• 单位中国医科大学; 长春大学