Angiogenesis as a therapeutic target in breast cancer

作者:Koutras Angelos K; Starakis Ioannis*; Lymperatou Dionysia; Kalofonos Haralabos P
来源:Mini Reviews in Medicinal Chemistry, 2012, 12(12): 1230-1238.

摘要

Current evidence indicates that angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Bevacizumab is a monoclonal antibody that targets the vascular endothelial growth factor (VEGF). Recent clinical data have demonstrated that the addition of bevacizumab to first-line chemotherapy improves the progression-free survival of patients with advanced breast cancer. This review presents an update on the role of bevacizumab, as well as other anti-angiogenic agents in the management of patients with breast carcinoma.

  • 出版日期2012-10