LIPOSOMAL CURCUMINOIDS FOR TRANSDERMAL DELIVERY: IONTOPHORESIS POTENTIAL FOR BREAST CANCER CHEMOTHERAPEUTICS

作者：Chang Chi Chang; Yang Wei Te; Ko Shun Yao; Hsu Yi Chiang^*

来源：Digest Journal of Nanomaterials and Biostructures, 2012, 7(1): 59-71.

• Curcuminoids
• Breast cancer
• Liposome
• Iontophoresis

Curcuminoids derived from the rhizomes of Curcuma longa have demonstrated anti-proliferation and the ability to induce apoptosis in cancer cells. This study selected curcuminoids as the model drug and liposome as a biocompatible and biodegradable carrier (liposome encapsulated curcuminoids; LEC). The iontophoresis technique was also investigated for its potential in facilitating the skin permeation of LEC. In-vitro permeation studies using a newborn pig skin indicated that iontophoresis (ITP) elevates the accumulation and flux of LEC, with a five-fold increase over that of curcuminoids without liposomal encapsulation (7.52 vs. 1.60 mu g/cm(2)). Results demonstrate that liposomal encapsulation could enhance and prolong the cytotoxicity of curcuminoids through an increase in the cellular uptake and transdermal delivery of curcuminoids in breast cancer therapy. The use of ITP could enable the transdermal delivery of liposome encapsulation during breast cancer therapy.

• 出版日期2012-3
• 单位河北医科大学