An efficient cascade synthesis of various 2H-1,4-benzoxazin-3-(4H)-ones from o-halophenols and 2-halo-amides catalyzed by CuI

作者：Chen Dingben; Shen Guodong; Bao Weiliang^*

来源：Organic and Biomolecular Chemistry, 2009, 7(19): 4067-4073.

DOI：10.1039/b906210f

A novel and efficient one-pot cascade synthesis of 2H-1,4-benzoxazin-3-(4H)-ones has been developed through copper-catalyzed coupling of o-halophenols and 2-halo-amides. Various 2H-1,4-benzoxazin-3-(4H)-ones with diversity at three substituents on their scaffold have been synthesized conveniently in good to excellent yields.

• 出版日期2009
• 单位台州学院; 浙江大学