How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale

作者：Han Sungwon; Lemire Joseph; Appanna Varun P; Auger Christopher; Castonguay Zachary; Appanna Vasu D^*

来源：Cell Biology and Toxicology, 2013, 29(2): 75-84.

DOI：10.1007/s10565-013-9239-0

• Aluminum toxicity
• Reactive oxygen species
• Mitochondrial dysfunction
• Dyslipidemia
• alpha-ketoacids
• Neurological and hepatic diseases

Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of alpha-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders.

• 出版日期2013-4