A Ruthenium-Catalyzed, Atom-Economical Synthesis of Nitrogen Heterocycles

作者:Trost Barry M*; Maulide Nuno; Livingston Robert C
来源:Journal of the American Chemical Society, 2008, 130(49): 16502-+.
DOI:10.1021/ja807696e

摘要

The Ruthenium catalyzed, atom-economical domino redox isomerization/cyclization of tethered aminopropargyl alcohols is reported. This process displays a broad scope and functional group tolerance, Furthermore, it presents a novel retrosynthetic disconnection linking simple and easily available, linear propargyl alcohols with added-value nitrogen heterocycles in a single catalytic step. [GRAPHICS]

  • 出版日期2008-12-10