A high serum level of M65 is associated with tumour aggressiveness and an unfavourable prognosis for epithelial ovarian cancer

作者：Yildiz Ibrahim^*; Tas Faruk; Kilic Leyla; Sen Fatma; Saip Pinar; Eralp Yesim; Keskin Serkan; Karabulut Senem; Ciftci Rumeysa; Serilmez Murat; Yasasever Vildan; Aydiner Adnan

来源：Cancer Chemotherapy and Pharmacology, 2013, 72(2): 437-444.

DOI：10.1007/s00280-013-2212-z

• Serum M65
• Biomarker
• Epithelial ovarian cancer
• Apoptosis
• Prognostic

This study was conducted to determine the clinical significance of serum M30 and M65 in epithelial ovarian cancer (EOC). %26lt;br%26gt;A total of 56 patients with EOC and 56 healthy women were included in the study. All of the patients received platinum-based chemotherapy. Pretreatment levels of M30 and M65 were measured using the quantitative ELISA method. %26lt;br%26gt;The median M30 and M65 serum levels were significantly elevated in the EOC patients compared with the healthy controls (96.7 vs. 69.5, p = 0.028 and 436.4 versus 166.3, p %26lt; 0.001, respectively). The cut-off value of 423.4 U/L for M65 determined with ROC analysis, predicted progression with 75.1 % sensitivity and 65.6 % specificity (AUC = 0.708, p = 0.008). Patients with higher M65 levels had shorter progression-free survival (PFS) (p = 0.021). Both M30 and M65 serum levels were significantly higher for serous-type histology (p = 0.001 and p %26lt; 0.001, respectively). Increased M65 serum levels were associated with advanced disease (p = 0.005) and higher grade (p = 0.005). Moreover, M65 levels were higher for chemotherapy-resistant patients (p = 0.04). Multivariate analysis revealed that an elevated serum M65 level was the only significant independent prognostic factor (p = 0.039, HR 3.792). %26lt;br%26gt;These results indicated that serum M30 and M65 levels were significantly elevated in patients with EOC compared with healthy women. Particularly, high serum M65 levels were associated with poor prognosis and resistance to platinum-based chemotherapy.

• 出版日期2013-8