An Integrated Approach to Thermal Analysis of Pharmaceutical Solids

作者：Riley Shelley R Rabel^*

来源：Journal of Chemical Education, 2015, 92(5): 932-935.

DOI：10.1021/ed500640d

• Upper-Division Undergraduate
• Analytical Chemistry
• Laboratory Instruction
• Hands-On Learning/Manipulatives
• Drugs/Pharmaceuticals
• Qualitative Analysis
• Quantitative Analysis
• Solid State Chemistry
• Thermal Analysis
• Instrumental Methods

A three-tiered experiment for undergraduate Instrumental Analysis students is presented in which students characterize the solid-state thermal behavior of an active pharmaceutical ingredient (acetaminophen) and excipient (alpha-lactose hydrate) using differential scanning calorimetry, thermogravimetric analysis, and thermal microscopy. Students are required to perform qualitative and quantitative analysis, incorporating data from the three thermal analysis techniques to successfully interpret melting, decomposition, and dehydration thermal transitions. Students use thermal analysis software to determine transition temperatures and enthalpies of transitions, and use stoichiometric calculations to calculate the water of hydration.

• 出版日期2015-5