Asymmetric Synthesis of Sphinganine and Clavaminol H

作者:Ait Youcef Ramzi; Moreau Xavier; Greck Christine*
来源:Journal of Organic Chemistry, 2010, 75(15): 5312-5315.
DOI:10.1021/jo1003899

摘要

An efficient enantioselective synthesis of sphinganine and clavaminol H is reported. These sphingoid-type bases were obtained from commercially available fatty acids using highly enantioselective Ru-catalyzed hydrogenation and organocatalytic electrophilic amination reactions to create the stereogenic centers.

  • 出版日期2010-8-6