A genetic variant in interleukin 8-251A/T is associated with the risk of clear cell renal cell carcinoma in Chinese population

作者：Chen, Chen; Wang, Xue-Lin; Zhang, Fei-Juan; Wang, Lin; Zhang, Ze; Lei, Ping; Feng, Shu-Zhi^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(2): 2307-2312.

• IL-8
• renal cell carcinoma
• single-nucleotide polymorphism
• risk

Background: Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies. However, there are no data about the role of IL-8 polymorphism in development of RCC. Patients and methods: A hospital-based case-control study was conducted among 520 patients with RCC and 520 healthy controls to investigate the possible association between the IL-8-251A/T and +781C/T polymorphisms respectively, and the risk of RCC. Results: Significant differences of genotype distribution were observed between RCC cases and controls at the IL-8-251T/A genotypes. Compared with the IL-8-251T/A homozygote TT, the heterozygous TA genotype was associated with significantly increased risk for RCC (OR = 1.83, 95% CI = 1.23-3.95, P = 0.019); the AA genotype was associated with increased risk for RCC (OR = 1.88, 95% CI = 1.29-3.68, P = 0.015). TA and AA combined variants were associated with increased risk for RCC compared with the TT genotype (OR = 1.85, 95% CI = 1.24-3.81, P = 0.018). Moreover, the genotype AA of IL-8-251T/A carried a higher risk of RCC metastasis and later stages, compared with the TT genotype. However, the genotype and allele frequencies of IL-8+ 781C/T polymorphisms in RCC patients were not significantly different from controls. Conclusion: Our results showed that the IL-8-251A/T genotype was associated with increased risk for development and metastasis of RCC in Chinese Han population.

• 出版日期2016
• 单位天津医科大学