alpha,alpha-Difluoro-alpha-phenylsulfanyl-alpha-trimethylsilylmethane as %26quot;(CF2-)-C-center dot%26quot; synthetic building block for the preparation of gem-difluoromethylenated cyclopentanols

作者：Peewasan Krisana; Kuhakarn Chutima; Soorukram Darunee; Tuchinda Patoomratana; Reutrakul Vichai; Pohmakotr Manat^*

来源：Journal of Fluorine Chemistry, 2012, 135: 367-372.

DOI：10.1016/j.jfluchem.2011.10.009

• alpha,alpha-Difluoro-alpha-phenylsulfanyl-alpha-trimethylsilylmethane
• gem-Difluoromethylenated cyclopentanols
• Radical cyclization

A general strategy for the preparation of gem-difluoromethylenated cyclopentanols has been demonstrated; it involves sequential fluoride-catalyzed nucleophilic addition of alpha,alpha-difluoro-alpha-phenylsulfanyl-alpha-trimethylsilylmethane (PhSCF2SiMe3; 1) to homoallyl ketones followed by intramolecular radical cyclization.

• 出版日期2012-3