Lamivudine Monotherapy-Based cART Is Efficacious for HBV Treatment in HIV/HBV Coinfection When Baseline HBV DNA <20,000 IU/mL

作者：Li, Yijia; Xie, Jing; Han, Yang; Wang, Huanling; Zhu, Ting; Wang, Nidan; Lv, Wei; Guo, Fuping; Qiu, Zhifeng; Li, Yanling; Song, Xiaojing; Thio, Chloe L.; Li, Taisheng^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2016, 72(1): 39-45.

DOI：10.1097/QAI.0000000000000927

• HIV
• HBV
• lamivudine
• tenofovir
• hepatitis B surface antigen

Background: Although combination antiretroviral therapy (cART) including tenofovir (TDF)+lamivudine (3TC) or emtricitabine (FTC) is recommended for treatment of HIV/HBV coinfected patients, TDF is unavailable in some resource-limited areas. Some data suggest that 3TC monotherapy-based cART may be effective in patients with low pretreatment HBV DNA. @@@ Methods: Prospective study of 151 Chinese HIV/HBV coinfected subjects of whom 60 received 3TC-based cART and 91 received TDF+3TC-based cART. Factors associated with HBV DNA suppression at 24 and 48 weeks, including anti-HBV drugs, baseline HBV DNA, and baseline CD4 cell count, were evaluated overall and stratified by baseline HBV DNA using Poisson regression with a robust error variance. @@@ Results: Baseline HBV DNA >= 20,000 IU/mL was present in 48.3% and 44.0% of subjects in the 3TC and TDF groups, respectively (P = 0.60). After 48 weeks of treatment, HBV DNA suppression rates were similar between these 2 groups (96.8% vs. 98.0% for 3TC and TDF+ 3TC, P > 0.999) in subjects with baseline HBV DNA <20,000 IU/mL; whereas in those with baseline HBV DNA >= 20,000 IU/mL, TDF+ 3TC was associated with higher suppression rates (34.5% vs. 72.5% in 3TC and TDF+ 3TC groups, respectively, P = 0.002). In stratified multivariate regression, TDF use (RR 1.98, P = 0.010) and baseline HBV DNA (per 1 log increase in International Units Per Milliliter, RR 0.74, P < 0.001) were associated with HBV DNA suppression only when baseline HBV DNA 20,000 IU/mL. @@@ Conclusion: This study suggests that 3TC monotherapy-based cART is efficacious for HBV treatment through 48 weeks in HIV/HBV coinfection when baseline HBV DNA <20,000 IU/mL. Studies with long-term follow-up are warranted to determine if this finding persists.

• 出版日期2016-5-1
• 单位中国医学科学院北京协和医院