Differences in Regional Glucose Metabolism of the Brain Measured with F-18-FDG-PET in Patients with Essential Tremor According to Their Response to Beta-Blockers

作者：Song In Uk; Ha Sang Won; Yang Young Soon; Chung Yong An^*

来源：Korean Journal of Radiology, 2015, 16(5): 967-972.

DOI：10.3348/kjr.2015.16.5.967

• Essential tremor
• Beta-blockers
• FDG-PET

Objective: In this study, there was an investigation as to whether there is a functional difference in essential tremor (ET), according to responses to beta-blockers, by evaluating regional changes in cerebral glucose metabolism.
Materials and Methods: Seventeen male patients with ET were recruited and categorized into two groups: 8 that responded to medical therapy (group A); and 9 that did not respond to medical therapy (group B). Eleven age-sex matched healthy control male subjects were also included in this study. All subjects underwent F-18 fLuorodeoxyglucose (FDG)-PET, and evaluated for their severity of tremor symptoms, which were measured as a score on the Fahn-Tolosa-Marin tremor rating scale (FTM). The FDG-PET images were analyzed using a statistical parametric mapping program.
Results: The mean FTM score 6 months after the initiation of propranolol therapy was significantly Lower in group A (18.13 > 8.13), compared with group B (14.67 = 14.67). The glucose metabolism in group A in the Left basal ganglia was seen to be decreased, compared with group B. The ET showed a more significantly decreased glucose metabolism in both the fronto-temporo-occipital Lobes, precuneus of right parietal lobe, and both cerebellums compared with the healthy controls.
Conclusion: Essential tremor is caused by electrophysiological disturbances within the cortical-cerebellar networks and degenerative process of the cerebellum. Furthermore, ET may have different pathophysiologies in terms of the origin of disease according to the response to first-Line therapy.

• 出版日期2015-10