Antineuronal antibodies in sporadic late-onset cerebellar ataxia

作者：Buerk K^*; Wick M; Roth G; Decker P; Voltz R

来源：Journal of Neurology, 2010, 257(1): 59-62.

DOI：10.1007/s00415-009-5262-8

• Voltage-gated calcium channels
• VGCC
• Idiopathic late onset cerebellar ataxia
• Multiple system atrophy
• Paraneoplastic cerebellar degeneration

Sporadic late-onset cerebellar ataxia of unknown cause is considered a neurodegenerative disorder whose underlying mechanisms are still unknown. To identify antineuronal autoantibodies, immunohistochemical and immunoblotting techniques were performed in 67 patients with sporadic cerebellar degeneration of unknown cause. Elevated P/Q-type voltage-gated calcium channel (VGCC)-specific antibodies were found in eight patients (11.9%). There was no hint of a paraneoplastic disorder in any of the patients. The present findings suggest an autoimmune contribution to the pathophysiology of a subgroup of sporadic late-onset cerebellar ataxia.

• 出版日期2010-1