ULTRASOUND IMPROVES THE UPTAKE AND DISTRIBUTION OF LIPOSOMAL DOXORUBICIN IN PROSTATE CANCER XENOGRAFTS

作者：Eggen Siv^*; Afadzi Mercy; Nilssen E**en A; Haugstad Solveig Bjaerum; Angelsen Bjorn; Davies Catharina de L

来源：Ultrasound in Medicine and Biology, 2013, 39(7): 1255-1266.

DOI：10.1016/j.ultrasmedbio.2013.02.010

• Ultrasound exposure
• Liposomal doxorubicin
• Drug delivery
• Drug release
• Microdistribution
• Biodistribution

Combining liposomally encapsulated cytotoxic drugs with ultrasound exposure has improved the therapeutic response to cancer in animal models; however, little is known about the underlying mechanisms. This study focused on investigating the effect of ultrasound exposures (1 MHz and 300 kHz) on the delivery and distribution of liposomal doxorubicin in mice with prostate cancer xenografts. The mice were exposed to ultrasound 24 h after liposome administration to study the effect on release of doxorubicin and its penetration through the extracellular matrix. Optical imaging methods were used to examine the effects at both microscopic subcellular and macroscopic tissue levels. Confocal laser scanning microscopy revealed that ultrasound-exposed tumors had increased levels of released doxorubicin compared with unexposed control tumors and that the distribution of liposomes and doxorubicin through the tumor tissue was improved. Whole-animal optical imaging revealed that liposomes were taken up by both abdominal organs and tumors. (E-mail: siv.eggen@ntnu.

• 出版日期2013-7