Unraveling the Biological Roles of Reactive Oxygen Species

作者:Murphy Michael P*; Holmgren Arne; Larsson Nils Goeran; Halliwell Barry; Chang Christopher J; Kalyanaraman Balaraman; Rhee Sue Goo; Thornalley Paul J; Partridge Linda; Gems David; Nystrom Thomas; Belousov Vsevolod; Schumacker Paul T; Winterbourn Christine C
来源:Cell Metabolism, 2011, 13(4): 361-366.
DOI:10.1016/j.cmet.2011.03.010

摘要

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.