A New 24-membered Lactone and a New Polyene delta-Lactone from the Marine Bacterium Bacillus marinus

作者：Xue, Chunmei; Tian, Li; Xu, Minjuan; Deng, Zhiwei; Lin, Wenhan^*

来源：Journal of Antibiotics, 2008, 61(11): 668-674.

DOI：10.1038/ja.2008.94

• Bacillus marinus
• macrolactin T
• macrolactin U
• structural elucidation
• antibiotic activity

A new 24-membered macrolide macrolactin T (1), and a new polyene delta-lactone macrolactin U (2), along with macrolactins A, B, D, O, and S, were isolated from the cultured broth of the bacterium Bacillus marinus, which was isolated from Suaeda salsa collected in the coastline of Bohai Sea of China. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data analyses. The inhibitory activity of macrolactins T. B and D against fungi Pyricularia oryzae and Alternaria solani, and bacteria Staphylococcus aureus is reported.

• 出版日期2008-11
• 单位北京大学; 国家海洋局第一海洋研究所; 北京师范大学; 天然药物与仿生药物国家重点实验室; 青岛科技大学