Multifunctional nanocarriers and intracellular drug delivery

作者：Sawant Rupa R; Torchilin Vladimir P^*

来源：Current Opinion in Solid State & Materials Science, 2012, 16(6): 269-275.

DOI：10.1016/j.cossms.2012.09.001

• Ligand-targeted
• Long-circulating
• Multimodal imaging
• Theranostics
• Stimuli-sensitive
• Nanocarriers
• Intracellular delivery
• Cell-penetrating peptide

Multifunctional nanocarriers for the delivery and targeting of therapeutic and diagnostic agents in cancer therapy have received significantly increased interest in recent years.
Several multifunctional nanocarriers engineered from a wide range of materials with consolidation of various functionalities for long circulation, targetability, stimuli-sensitivity, intracellular delivery for therapy and imaging have been shown to be capable of killing the desired target diseased cells with minimal side effects to provide enhanced contrast during imaging for disease location and monitor both the fate of the nanocarrier and treatment in real time. This review highlights recent advances in the design and engineering of multifunctional nanocarriers, along with the importance of intracellular delivery.

• 出版日期2012-12
• 单位东北大学