An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-gamma-amino Alcohols Starting from alpha,beta-Unsaturated Ketones in Flow

作者：Ballerini Eleonora; Maggi Raimondo; Pizzo Ferdinando; Piermatti Oriana; Gelman Dmitri^*; Vaccaro Luigi^*

来源：Organic Process Research & Development, 2016, 20(2): 474-479.

DOI：10.1021/acs.oprd.5b00163

We report herein a clean multistep flow process that starting from a alpha,beta-unsaturated ketones 1 allows the preparation of N-Boc-gamma-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.

• 出版日期2016-2