Does High Protein Intake During First Week of Life Improve Growth and Neurodevelopmental Outcome at 18 months Corrected Age in Extremely Preterm Infants?

作者：Buddhavarapu Siddartha; Manickaraj Saranya; Lodha Abhay; Soraisham Amuchou Singh^*

来源：Indian Journal of Pediatrics, 2016, 83(9): 915-921.

DOI：10.1007/s12098-015-1918-9

• Growth
• Neurodevelopmental outcomes
• Preterm
• Protein
• Neonate

Objective To examine whether high protein intake during the first week of life alters the growth and neurodevelopmental outcomes at 18 mo corrected age (CA) in preterm infants born < 29 wk.
Methods This was a retrospective cohort study of preterm infants (< 29 wk) before and after introduction of nutritional policy targeting higher protein intake during the first week of life. The authors compared the growth and neurodevelopmental outcomes at 18 mo CA between infants born before (epoch 1) and after (epoch 2) the introduction of nutrition policy.
Results Of 171 eligible infants who completed follow-up at 18 mo CA, 87 (51 %) were in post intervention group (epoch 2). The mean (+/- SD) gestational age (26.3 +/- 1.49 wk vs. 26.2 +/- 1.48 wk) and birth weight (947 +/- 220 g vs. 924 +/- 225 g) were similar between the two groups. At 18 mo CA, there were no significant differences in the growth and neurodevelopmental impairment rates between the two groups. Logistic regression analysis revealed that high protein intake (> 3.5 g/kg/d) was not associated with improved neurodevelopmental outcome (OR 1.49, 95 % CI 0.52-4.26).
Conclusions High protein intake during the first week of age was not associated with better growth or neurodevelopmental outcome at 18 mo CA in preterm infants.

• 出版日期2016-9