New phenolics from the root of Scutellaria prostrata JACQ. ex BENTH.

作者：Bhat Gulzar; Ganai Bashir A; Shawl Abdul S^*

来源：Natural Product Research, 2014, 28(20): 1685-1690.

DOI：10.1080/14786419.2014.939082

• Scutellaria prostrata
• biflavonoids
• phenolics
• phenylethanoids
• antioxidant
• antimicrobial
• cytotoxic activity

Scutellaria prostrata (Lamiaceae), a perennial herb growing as a lonely species in Kashmir, Himalayas, was subjected to repetitive column and flash chromatographic isolation for its chemical documentation-cum-bioevaluation. The methanolic extract of S. prostrata afforded the isolation of ten compounds (1-10), including two new compounds - scutellapbiflavanone (1) and scutellaprostin M(2). The known compounds were found to be scutellarin (3), hispidulin-7-O-beta-D-glucopyranoside (4), baicalin (5), wogonoside (6), scutellaprostin C (7), acetoside (8), martynoside (9) and scutellaric acid-3-O-beta-D-glucopyranoside (10). Isolation of biflavonoids, phenolics and phenylethanoid compounds from S. prostrata seals a deal of chemotaxonomic importance of this particular species. The characterisation of the compounds was achieved by H-1, C-13, H-1-H-1 DFQ COSY, HMBC, HSQC, HMQC and ROESY NMR experiments. All the compounds were tested for antioxidant, antimicrobial and cytotoxic activities.

• 出版日期2014