Association between rs4938723 functional polymorphism in the promoter region of miR-34b/c gene and cancer risk

作者：Liu, Qi; Yang, Guocan; Song, Xiao-Ling; Wang, Zongxin; Shi, Ge^*

来源：Clinics and Research in Hepatology and Gastroenterology, 2015, 39(4): 526-533.

DOI：10.1016/j.clinre.2014.10.007

• HEPATOCELLULAR-CARCINOMA
• CELL-PROLIFERATION
• MICRORNA-34 FAMILY
• COLORECTAL-CANCER
• PRI-MIR-34B/C
• METHYLATION
• METASTASIS
• GROWTH
• MIRNA
• P53

Genetic polymorphism of miR-34b/c gene is a candidate factor for attributing predisposition to carcinoma. However, results of mounting studies, concerning association of miR-34b/c gene rs4938723 with risk of cancer, present contradictory results. Therefore, a meta-analysis was performed to systematically assessment the possible association between them. The overall results of meta-analysis indicate a significant association was only observed between rs4938723 and cancer risk in genotype model (P-h = 0.203, OR = 1.09, 95% CI = 1.01-1.70 for CT vs. TT). After stratifying by ethnicity and cancer type, genotype CT of rs4938723 was significantly association with an increased cancer risk in Asian population (P-h = 0.187, OR = 1.10, 95% CI = 1.01-1.20), allele C and genotype CT were significantly positive associated with hepatocellular cancer (P-h = 0.113, OR = 1.11, 95% CI = 1.01-1.23 for C vs. T; P-h = 0.121, OR = 1.19, 95% CI = 1.03-1.37 for CT vs. TT), but rs4938723 was negative associated with risk of colorectal cancer (P-h = 0.342, OR = 0.66, 95% CI = 0.47-0.92 for CC vs. TT; P-h = 0.519, OR = 0.67, 95% CI = 0.49-0.93 for CC vs. CT/TT; P-h = 0.443, OR = 0.71, 95% CI = 0.51-0.99 for CC/TT vs. CT). These findings suggested that rs4938723 was a susceptible locus only for hepatocellular cancer and colorectal cancer.

• 出版日期2015-9
• 单位浙江大学; 复旦大学; 绍兴市人民医院