A new, third generation, PVC/TTF-TCNQ composite amperometric biosensor for glucose determination

作者：Cano Manuel; Avila J Luis; Mayen Manuel; Mena M L; Pingarron J; Rodriguez Amaro Rafael^*

来源：Journal of Electroanalytical Chemistry, 2008, 615(1): 69-74.

DOI：10.1016/j.jelechem.2007.11.032

• TTF-TCNQ
• composite electrode
• biosensor
• glucose
• flow injection

A simple and effective amperometric biosensor based on PVC/TTF-TCNQ composite electrode is proposed for glucose determination. Glucose oxidase (GOx) was immobilized by crosslinking with glutaraldehyde. The TTF-TCNQ salt acts as a conducting phase and as a redox mediator, without needing the addition of any other substance. The biosensor can be applied in batch (response linear up to 5.0 mM, with a limit of detection, s/n = 3, of 8.5 x 10(-6) M) and in FIA systems (linear range between 0. 1 and 8.0 mM, with a limit of detection, s/n = 3, of 1.9 x 10(-5) M). It is also proposed a simple procedure that allows glucose and ascorbic acid to be simultaneously determined.

• 出版日期2008-4-1