Novel synthesis of N-alkyl amines from tandem coupling of either methylamine or nitroalkane with aldehyde

作者：Lu, Shuanglong; Peng, Jie; Wu, Junjie; Li, Chao; Cao, Xueqin; Gu, Hongwei^*

来源：Chemical communications, 2016, 52(4): 760-763.

DOI：10.1039/c5cc07807e

• ASYMMETRIC REDUCTIVE AMINATION
• HENRY REACTION
• SECONDARY-AMINES
• SELECTIVE SYNTHESIS
• MOLECULAR-HYDROGEN
• CARBON-DIOXIDE
• METHYLATION
• NANOWIRES
• CATALYSIS
• NITRILES

A novel tandem strategy for coupling of either methylamine or nitroalkane with aldehyde has been developed. This is the first demonstration that methylamine or nitroalkane is used as a methylation reagent, fabricating N-alkyl amines. The active Pt NWs allow for the selective preparation of a series of N-alkyl amines with good to excellent yields under mild and environmentally friendly conditions.

• 出版日期2016
• 单位苏州大学