An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3 %26apos;]-pyrrolidine and Spiro[oxindole-3,2 %26apos;-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

作者：Arumugam Natarajan; Almansour Abdulrahman I; Kumar Raju Suresh; Carlos Menendez J; Sultan Mujeeb A; Karama Usama; Ghabbour Hazem A; Fun Hoong Kun

来源：Molecules, 2015, 20(9): 16142-16153.

DOI：10.3390/molecules200916142

• multicomponent reactions
• 1
• 3-dipolar cycloaddition reactions
• spirooxindoles
• spiropyrrolidines
• ionic liquids

A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10-benzylideneanthracen-9(10H)-one as a dipolarophile in 1-butyl-3-methylimidazolium bromide([bmim]Br), an ionic liquid. This reaction proceeded regio- and diastereoselectively, in good to excellent yields.

• 出版日期2015-9