A beta-Boronopeptide Bundle of Known Structure As a Vehicle for Polyol Recognition

作者:Melicher Michael S; Chu John; Walker Allison S; Miller Scott J*; Baxter Richard H G; Schepartz Alanna
来源:Organic Letters, 2013, 15(19): 5048-5051.
DOI:10.1021/ol402381n

摘要

Despite significant progress in the design of receptors and sensors for simple polyols and monosaccharides, few synthetic receptors discriminate among multiple saccharide units simultaneously, especially under physiological conditions. Described here is the three-dimensional structure of a supramolecular complex-a beta-peptide bundle-designed for the potential to interact simultaneously with as many as eight discrete monosaccharide units. The preliminary evaluation of this construct as a vehicle for polyol binding is also presented.

  • 出版日期2013-10-4