Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography

作者:Zang, Pengxiao; Liu, Gangjun; Zhang, Miao; Wang, Jie; Hwang, Thomas S.; Wilson, David J.; Huang, David; Li, Dengwang*; Jia, Yali*
来源:Journal of Biomedical Optics, 2017, 22(2): 026001.
DOI:10.1117/1.JBO.22.2.026001

摘要

We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.