Allelic Imbalances in Radiation-Associated Acute Myeloid Leukemia

作者：Klymenko Sergiy V; Smida Jan; Atkinson Michael J; Bebeshko Volodymir G; Nathrath Michaela; Rosemann Michael^*

来源：Genes, 2011, 2(2): 384-393.

DOI：10.3390/genes2020384

• acute myeloid leukemia
• ionizing radiation
• Chernobyl accident
• single nucleotide polymorphism
• microarray

Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.

• 出版日期2011-6