Hepatic Resection Assisted by Ablative Therapy for Advanced Hepatocellular Carcinoma

作者：Hiraoka Atsushi^*; Tazuya Nayu; Hidaka Satoshi; Uehara Takahide; Ichiryu Misa; Nakahara Masahiro; Tanabe Atsushi; Shimizu Yukou; Tanihira Tetsuya; Hasebe Aki; Miyamoto Yasunao; Ninomiya Tomoyuki; Kawasaki Hideki; Ochi Hironori; Koizumi Yohei; Hirooka Masashi; Abe Masanori; Hiasa Yoichi; Matsuura Bunzo; Onji Morikazu; Michitaka Kojiro

来源：Hepato-Gastroenterology, 2011, 58(107): 955-959.

• Hepatocellular carcinoma
• Hepatic resection
• Radiofrequency ablation
• Ethanol injection
• Combination therapy

Background/Aims: We attempted combinations of resection and ablative therapies (ethanol injection (El) or radiofrequency therapy (RFA)) in hepatocellular carcinoma (HCC) patients.
Methodology: Thirty-one patients with naive HCC treated from January 2000 to June 2010 were enrolled. All were tumor node metastasis stage HI and the number of tumors was countable (<= 5). Twelve were treated with resection assisted with an ablative therapy (combination group) and 19 with resection only (resection group). Clinical backgrounds and prognosis were investigated.
Results: The total scores for up-to-seven criteria were larger in the combination group than in the resection group (p=0.01), while other clinical background findings were not significantly different between the groups. In the combination group, 10 cases underwent resection combined with RFA and 2 with El. The 1- and 3-year survival rates were not significantly different between the groups (combination group, 88.2% and 88.2%, respectively; resection group, 90.9% and 80.8%, respectively). There were no severe complications.
Conclusion: Our results indicate that combination therapy is a therapeutic option for cases with countable HCCs who are difficult to treat by resection only.

• 出版日期2011-6