科研之友
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摘要
This study was performed to determine if there is an age-related specificity in the response of muscle protein metabolism to severe burn injury during acute hospitalization. This is a retrospective analysis of previously published data.
Nineteen adult and 58 pediatric burn-injured patients (age 43.3 +/- A 14.3 vs. 7.2 +/- A 5.3 years, adult vs. children) participated in stable isotope [ring-(2)H(5)]phenylalanine (Phe) infusion studies. Femoral arterial and venous blood samples and muscle biopsy samples were collected throughout the study. Data are presented as means +/- A standard deviation (SD). A p value less than 0.05 was considered statistically significant.
Muscle net protein balance (NB) was higher in children (adult vs. children, -43 +/- A 61 vs. 8 +/- A 68 nmol Phe/min/100 ml leg volume, p < 0.05). Muscle protein fractional synthesis rate (FSR) was higher in children (adult vs. children, 0.11 +/- A 0.05 vs. 0.16 +/- A 0.10 %/h, p < 0.05). Leg muscle protein breakdown was not different between the groups (adult vs. children, 179 +/- A 115 vs. 184 +/- A 124 nmol Phe/min/100 ml leg volume, p > 0.05); synthesis rate was 134 +/- A 96 and 192 +/- A 128 nmol Phe/min/100 ml leg volume in adults and children, respectively (p = 0.07). Age significantly correlated with muscle protein NB (p = 0.01) and FSR (p = 0.02); but not with breakdown (p = 0.67) and synthesis (p = 0.07) rates measured by using a three-pool model.
In burn injury, the muscle protein breakdown may be affected to the same extent in adults and children, whereas synthesis may have age-related specificities, resulting in a better but still low NB in children.
- 出版日期2011-8
