Allergic immune-regulatory effects of Adlay Bran on an OVA-immunized mice allergic model

作者：Chen Hong Jhang; Hsu Hsin Yi^*; Chiang Wenchang

来源：Food and Chemical Toxicology, 2012, 50(10): 3808-3813.

DOI：10.1016/j.fct.2012.07.011

• Allergy
• Flavonoids
• Adlay bran
• Th2 cytokines
• Anti-OVA IgE

Allergy is an inflammation associated with an elevated T helper (Th) 2 lymphocyte responses to allergens and elevated serum IgE levels and cytokines. In one of our previous studies using a cell model, various flavonoids were found to be involved the anti-inflammatory effects of adlay bran. The present study investigated the effect of the ethyl-acetate fraction of ethanolic extract of adlay bran (ABE-EtOAc) in an ovalbumin (OVA)-immunized murine model. Six-week-old female BALB/c mice underwent OVA sensitization and were used as an allergy model. An orogastric gavage was used to force feed these mice with 240 mg/kg ABE-EtOAc from their sixth week through their twelfth week Immune reactions were determined by measuring changes in Th2-type cytokine (IL-4 and IL-5) levels and production of antibodies. ABE-EtOAc was found capable of regulating the Th1/Th2 immune reaction through its regulation of IL-2 and IL-4. It also significantly reduced the production of anti-OVA IgE antibodies (10%), increased the secretion of IFN-gamma and decreased the secretion of I1-6 (38%). These results suggest that adlay bran extract can reduce an allergic reaction by balancing Th1/Th2 immune responses and that it might be used in the treatment of this condition.

• 出版日期2012-10