A Clean Procedure for Synthesis of Pyrido[d]Pyrimidine Derivatives Under Solvent-Free Conditions Catalyzed by ZrO2 Nanoparticles

作者：Abdolmohammadi Shahrzad^*; Balalaie Saeed

来源：Combinatorial Chemistry & High Throughput Screening, 2012, 15(5): 395-399.

DOI：10.2174/138620712800194486

• Solvent-free
• tandem knoevenagel-michael addition
• tetrahydropyrido[d]pyrimidine
• ZrO2 nanoparticles

A simple one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3-d] pyrimidine-6-carbonitriles 4 from aromatic aldehydes, malononitrile and 4(6)-aminouracil in the presence of ZrO2 nanoparticles (ZrO2 NPs) as an efficient heterogeneous catalyst is described. The procedure has the advantages of high yields (86-97%), short reaction time (2h) and an environmentally friendly specificity.
[GRAPHICS]
.

• 出版日期2012-6