HES solutions in critical illness, trauma and perioperative period

作者：Baronica Robert^*; Pavlovic Daniela Bandic; Drvar Zeljko; Sakan Sanja; Tonkovic Dinko; Baronica Koraljka Bacic

来源：Signa Vitae, 2014, 9: 15-20.

• hydroxyethyl starches
• critical illness
• perioperative period

In the last few years, many studies and meta-analyses have demonstrated that hydroxyethyl starch (HES) solutions increase the risk of acute renal failure and mortality in critically ill patients. Some studies suggest complete avoidance of HES solutions in patients of all categories. On the other hand, recent studies and analyses suggest that HES solutions may be used in hypovolemic critically ill patients and in the perioperative setting. The main problem in everyday clinical practice and in a rational fluid management approach is that treatment with alternatives to HES solutions is not always pathophysiologically justified (crystalloids) or confirmed in randomised controlled trials (gelatins, albumins).

• 出版日期2014