Desorption of artemisinin extracts of CIM-Arogya by supercritical carbon dioxide

作者：Negi Arvind Singh; Cortesi Angelo^*; Kikic Ireneo; Bertucco Alberto; Calabrese Massimo; Solinas Dario

来源：Journal of Supercritical Fluids, 2018, 133: 42-48.

DOI：10.1016/j.supflu.2017.09.024

• Artemisinin
• Supercritical carbon dioxide
• Soxhlet extraction
• Supercritical desorption

Artemisinin is a drug for chloroquine resistant malaria and cerebral malaria treatments. In the recent past, there was an acute shortage of this drug and hence World Health Organization made a strategy to fulfil the Artemisinin demand.
In this study, artemisinin was extracted by supercritical Carbon Dioxide (SFCO2) from CIM-Arogya, a variety of Artemisia annua, in temperature and pressure ranges of 313.1-333.1 K and 15-25 MPa. Artemisinin global yield isotherms were determined obtaining a maximum yield of 3.65 wt%. Artemisinin extracts were also obtained by hexane Soxhlet extraction: then, the crude extracts were purified using SFCO2, after adsorption on silica gel. Different desorption runs were performed with a 6 ml/min CO2 flow rate, in temperature and pressure ranges of 313.1-333.1 K and 15-25 MPa. At different time intervals, extracts were collected and analysed: their yields varied from 2.75% to 4.34% function of the experimental conditions. Desorption trials were also correlated with different models.

• 出版日期2018-3