MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

作者：Kavitha Nowroji; Vijayarathna Soundararajan; Jothy Subramanion Lachumy; Oon Chern Ein; Chen Yeng; Kanwar Jagat Rakesh; Sasidharan Sreenivasan^*

来源：Asian Pacific Journal of Cancer Prevention, 2014, 15(18): 7489-7497.

DOI：10.7314/APJCP.2014.15.18.7489

• Cell cycle control
• cancer
• miRNA dysregulation
• oncogene

MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.

• 出版日期2014
• 单位迪肯大学