A Comparison of Intravenous Oxycodone and Intravenous Morphine in Patient-Controlled Postoperative Analgesia After Laparoscopic Hysterectomy

作者：Lenz Harald^*; Sandvik Leiv; Qvigstad Erik; Bjerkelund Carl Eivind; Raeder Johan

来源：Anesthesia and Analgesia, 2009, 109(4): 1279-1283.

DOI：10.1213/ane.0b013e3181b0f0bb

INTRODUCTION: In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.
METHODS: Ninety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.
RESULTS: The accumulated oxycodone consumption was less (13.3 /- 10.4 mg Xis 22.0 /- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.
CONCLUSIONS: Oxycodone was more potent than morphine for visceral pain relief but not for sedation. (Anesth Analg 2009;109:1279-83)

• 出版日期2009-10